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Analysis of the GUSEL-regulated and the lesional and non-lesional psoriatic skin transcriptome in human patients
Overview
Dataset Name :
Analysis of the GUSEL-regulated and the lesional and non-lesional psoriatic skin transcriptome in human patients
Description :
Skin punch biopsies were obtained from non-lesional skin regioins from psoriatic patients prior to GUSEL administration. Skin punch biopsies were also obtained from lesional skin regions at baseline and at 1 -12 wk after treatment with 100 - 300 mg GUSEL.
Dataset Type :
Transcriptomic
Release Date :
June 11, 2021
DOI :
10.1621/rUkvIsuaQM
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE51440
Dataset Citation :
Sofen H, Smith S, Matheson RT, Leonardi CL, Calderon C, Brodmerkel C, Li K, Campbell K, Marciniak SJ Jr, Wasfi Y, Wang Y, Szapary P and Krueger JG (2021) Analysis of the GUSEL-regulated and the lesional and non-lesional psoriatic skin transcriptome in human patients, v 1.0 Signaling Pathways Project Datasets. 10.1621/rUkvIsuaQM
Download Citation :

Associated Article :
Sofen H, Smith S, Matheson RT, Leonardi CL, Calderon C, Brodmerkel C, Li K, Campbell K, Marciniak SJ Jr, Wasfi Y, Wang Y, Szapary P and Krueger JG. (2014) Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis. J. Allergy Clin. Immunol. 133 1032-40 View Abstract | View PubMed
Guselkumab (an IL-23-specific mAb) demonstrates clinical and molecular response in patients with moderate-to-severe psoriasis.

Experiments

There are 3 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | Lesional psoriatic skin vs Non-lesional psoriatic skin
  • 2 | GUSEL vs Baseline | 1 wk
  • 3 | GUSEL vs Baseline | 12 wk
Gene List
Experiment Information
Name : Lesional psoriatic skin vs Non-lesional psoriatic skin
Description :

Skin punch biopsies were obtained from non-lesional skin regioins from psoriatic patients prior to GUSEL administration.

Tissue/Cell line : other, whole skin
Species : Human
Additional Information