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The Signaling Pathways Project
A multi-omics knowledgebase for cellular signaling pathways
Time course transcriptomic analysis of all-trans retinoic acid (ATRA)-treated NB4 cells
Overview
Dataset Name :
Time course transcriptomic analysis of all-trans retinoic acid (ATRA)-treated NB4 cells
Description :
Wild type NB4 acute promyelocytic leukemia cells or NB4 cells in which transglutaminase 2 was knocked down were treated with or without 1 µM ATRA for 48 h or 72 h.
Dataset Type :
Transcriptomic
Release Date :
July 13, 2016
DOI :
10.1621/z04egxZq1P
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE23702
Dataset Citation :
Csomos K, Balajthy Z, Nagy I and Fesus L (2010) Time course transcriptomic analysis of all-trans retinoic acid (ATRA)-treated NB4 cells, v 1.0 Signaling Pathways Project Datasets. 10.1621/z04egxZq1P
Download Citation :
Associated Article :
Csomós K, Német I, Fésüs L and Balajthy Z (2010) Tissue transglutaminase contributes to the all-trans-retinoic acid-induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemia. Blood 116 3933-43 View Abstract | View PubMed
Tissue transglutaminase contributes to the all-trans-retinoic acid-induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemia.
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Experiments

There are 7 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | ATRA vs Veh | 1 µM, 48 h
  • 2 | ATRA vs Veh | 1 µM, 72 h
  • 3 | ATRA vs Veh (TGM2 KD) | 1 µM, 48 h
  • 4 | ATRA vs Veh (TGM2 KD) | 1 µM, 72 h
  • 5 | TGM2 KD vs WT (ATRA) | 1 µM, 48 h
  • 6 | TGM2 KD vs WT (ATRA) | 1 µM, 72 h
  • 7 | TGM2 KD vs WT
Gene List
Experiment Information
Name : ATRA vs Veh | 1 µM, 48 h
Description :

Human NB4 acute promyelocytic leukemia cells were treated with or without 1 µM ATRA for 48 hrs. This is the first of seven contrasts investigating the role of ATRA during NB4 cell differentiation.
Tissue/Cell line : myeloid lineage, promyelocytes, APL, NB4 cells
Species : Human
Additional Information
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