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The Signaling Pathways Project
A multi-omics knowledgebase for cellular signaling pathways
Analysis of the dystrophin (Dmd)-dependent transcriptome in mouse skeletal muscle
Overview
Dataset Name :
Analysis of the dystrophin (Dmd)-dependent transcriptome in mouse skeletal muscle
Description :
Skeletal muscle (diaphragm, extensor digitorum longus, gastrocnemius, quadriceps, soleus, and tibialis anterior) was isolated from 8 week old male Dmd mdx, Dmd mdx5cv, and WT mice. The mdx mouse has a nonsense mutation in exon 23 of dystrophin and the mdx5cv mouse has a mutation in exon 10 of dystrophin. Both mice lack dystrophin.
Dataset Type :
Transcriptomic
Release Date :
January 24, 2018
DOI :
10.1621/84ZEQZvZ8k
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE897
Dataset Citation :
Haslett JN, Kho AT, Han M, Sanoudou D, Volinski JM, Beggs AH, Kohane IS, Kunkel LM and Kohane IS (2005) Analysis of the dystrophin (Dmd)-dependent transcriptome in mouse skeletal muscle, v 1.0 Signaling Pathways Project Datasets. 10.1621/84ZEQZvZ8k
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Associated Article :
Haslett JN, Kang PB, Han M, Kho AT, Sanoudou D, Volinski JM, Beggs AH, Kohane IS and Kunkel LM (2005) The influence of muscle type and dystrophin deficiency on murine expression profiles. Mamm. Genome 16 739-48 View Abstract | View PubMed
The influence of muscle type and dystrophin deficiency on murine expression profiles.
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Experiments

There are 12 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | Dmd mdx vs WT - diaphragm
  • 2 | Dmd mdx5cv vs WT - diaphragm
  • 3 | Dmd mdx vs WT - extensor digitorum longus
  • 4 | Dmd mdx5cv vs WT - extensor digitorum longus
  • 5 | Dmd mdx vs WT - gastrocnemius
  • 6 | Dmd mdx5cv vs WT - gastrocnemius
  • 7 | Dmd mdx vs WT - quadriceps
  • 8 | Dmd mdx5cv vs WT - quadriceps
  • 9 | Dmd mdx vs WT - soleus
  • 10 | Dmd mdx5cv vs WT - soleus
  • 11 | Dmd mdx vs WT - tibialis anterior
  • 12 | Dmd mdx5cv vs WT - tibialis anterior
Gene List
Experiment Information
Name : Dmd mdx vs WT - diaphragm
Description :

Diaphragm muscle was isolated from 8 week old male Dmd mdx and WT mice. The mdx mouse has a nonsense mutation in exon 23 of dystrophin and lacks dystrophin.
Tissue/Cell line : diaphragm
Species : House Mouse
Additional Information
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