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Analysis of the peroxisome proliferator activated receptor α (PPARα/Ppara)- and perfluorooctanoic acid (PFOA)-regulated transcriptomes in mouse liiver
Overview
Dataset Name :
Analysis of the peroxisome proliferator activated receptor α (PPARα/Ppara)- and perfluorooctanoic acid (PFOA)-regulated transcriptomes in mouse liiver
Description :
Liver was isolated from male 129S4/SvJae-Pparatm1Gonz/J PPARα/Ppara knockout or wild type mice treated with 3 mg/kg/d PFOA or vehicle for 7 d or 10 d.
Dataset Type :
Transcriptomic
Release Date :
August 05, 2015
DOI :
10.1621/Z2mx7YCBjw
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE9786
Dataset Citation :
Rosen MB,  Lee JS,  Ren H,  Vallanat B,  Liu J,  Waalkes MP,  Abbott BD,  Lau C and  Corton JC (2008) Analysis of the peroxisome proliferator activated receptor α (PPARα/Ppara)- and perfluorooctanoic acid (PFOA)-regulated transcriptomes in mouse liiver, v 1.0 Signaling Pathways Project Datasets. 10.1621/Z2mx7YCBjw
Download Citation :

Associated Article :
Rosen MB, Lee JS, Ren H, Vallanat B, Liu J, Waalkes MP, Abbott BD, Lau C and Corton JC (2008) Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR. Toxicol. Sci. 103 46-56 View Abstract | View PubMed
Toxicogenomic dissection of the perfluorooctanoic acid transcript profile in mouse liver: evidence for the involvement of nuclear receptors PPAR alpha and CAR.

Experiments

There are 4 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | PFOA vs Veh
  • 2 | PFOA vs Veh (PPARα/Ppara KO)
  • 3 | PPARα/Ppara KO vs WT (Veh)
  • 4 | PPARα/Ppara KO vs WT (PFOA)
Gene List
Experiment Information
Name : PFOA vs Veh
Description :

Liver was isolated from male 129S1/SvlmJ wild-type mice treated with 3 mg/kg/d PFOA or vehicle for 7 d.

Tissue/Cell line : whole liver
Species : House Mouse
Additional Information