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Analysis of the severe acute respiratory syndrome coronavirus (SARS-CoV-1 and SARS-CoV-2)-dependent transcriptome in human small intestinal organoids
Overview
Dataset Name :
Analysis of the severe acute respiratory syndrome coronavirus (SARS-CoV-1 and SARS-CoV-2)-dependent transcriptome in human small intestinal organoids
Description :
Human small intestinal organoids established from primary gut epithelial stem cells were mock infected or infected at a MOI of 1 with SARS-CoV-1 HKU 39849 or SARS-CoV-2 BetaCoV/Munich/BavPat1/2020 for 24 - 72 h. Cells were cultured in expansion medium or in differentiation media.
Dataset Type :
Transcriptomic
Release Date :
June 02, 2020
DOI :
10.1621/YF1blszQna
Version :
This is Version 1.0 of an annotated derivative of the original dataset, which can be found in GSE149312
Dataset Citation :
Lamers MM, Beumer J, van der Vaart J, Knoops K, Puschhof J, Breugem TI, Ravelli RB, van Schayck JP, Mykytyn AZ, Duimel HQ, van Donselaar E, Riesebosch S, Kuijpers HJ, Schipper D, van de Wetering WJ, de Graaf M, Koopmans M, Cuppen E, Peters PJ, Haagmans BL and Clevers H (2020) Analysis of the severe acute respiratory syndrome coronavirus (SARS-CoV-1 and SARS-CoV-2)-dependent transcriptome in human small intestinal organoids, v 1.0 Signaling Pathways Project Datasets. 10.1621/YF1blszQna
Download Citation :

Associated Article :
Lamers MM, Beumer J, van der Vaart J, Knoops K, Puschhof J, Breugem TI, Ravelli RBG, Paul van Schayck J, Mykytyn AZ, Duimel HQ, van Donselaar E, Riesebosch S, Kuijpers HJH, Schippers D, van de Wetering WJ, de Graaf M, Koopmans M, Cuppen E, Peters PJ, Haagmans BL and Clevers H (2020) SARS-CoV-2 productively infects human gut enterocytes Science 10.1126/science.abc1669 View Abstract | View PubMed
SARS-CoV-2 productively infects human gut enterocytes

Experiments

There are 2 Experiments for this dataset. Up to the 50 up and down p < 0.05 FDR data points are displayed for each. Please download the dataset to view all data points.

  • 1 | SARS-CoV-1 HKU 39849 vs Mock
  • 2 | SARS-CoV-2 BetaCoV/Munich/BavPat1/2020 vs Mock
Gene List
Experiment Information
Name : SARS-CoV-1 HKU 39849 vs Mock
Description :

Human small intestinal organoids established from primary gut epithelial stem cells were mock infected or infected at a MOI of 1 with SARS-CoV-1 HKU 39849 for 72 h.

Tissue/Cell line : small intestine, enteroids
Species : Human
Additional Information